Projects

MU OmicsLab develops its bioinformatics and computational toxicology direction through a portfolio of research projects, collaborative grants, and infrastructure initiatives. Here you’ll find the projects that currently define (and fund) our work—ranging from LLM-assisted pharmacogenomics and RNA/siRNA concepts, to environmental exposure toxicology and server-enabled reproducible bioinformatics.

If you’d like to collaborate, host a student, or request bioinformatics support → contact us · свържете се с нас

Active / recent projects

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Related Topics

• CardioPharmaGENET: LLM-based Pharmacogenomics Applications for Cardiovascular Precision Pharmacotherapy
  • Funding: National co-funding procedure for Bulgarian teams in approved COST Actions
  • Contract: КП-06-КОСТ/25/12.12.2025 г.
  • Principal Investigator: Assoc. Prof. Yordan Yordanov, PhD
  • Scientific field: Medical sciences
  • COST Action: CA24165 — Network for Cardiovascular Pharmacogenomics and Precision Medicine (CardioPharmaGENET)
  • Host organization: Medical University of Sofia
  • Project title: Pharmacogenomics applications of large language models and assessment of their impact on accessibility and readiness for integration in personalized cardiovascular pharmacotherapy
  • Duration: 24 months
  • Total budget: 50,000 BGN

  Contact: yyordanov@pharmfac.mu-sofia.bg

• DEFENDER: Design, synthesis and preclinical evaluation of compounds from the heterocyclic series with potential neuroprotective activity

  Funding: European Union — NextGenerationEU through the National Recovery and Resilience Plan of Bulgaria, project BG-RRP-2.004-0004-C01. Principal Investigators/Team Leads: Prof. Alexander Zlatkov; Prof. Virginia Tzankova Summary: Project Summary The project develops novel neuroprotective agents for Parkinson’s disease through in silico design, synthesis, and multi-level evaluation of xanthine derivatives (N-substituted 3-(1,3,7-trimethyl-xanthin-8-ylthio)propanehydrazides) and pyrrole derivatives targeting MAO-B inhibition, antioxidant activity, and neuroprotection. Key approaches include QSAR modeling, molecular docking, ADMET prediction, in vitro assays (HepG2, SH-SY5Y cells; ROS, GSH, MTT), and in vivo toxicity testing. Emphasis on multi-target drug design for complex neurodegenerative diseases, with computational screening yielding 6-36 lead compounds across work packages.

• BG–AT Collaboration: siRNA & nanosystems

  Funding: Bulgarian National Science Fund (BNSF), grant KP-06-Austria/10/21.08.2023. Principal Investigator/Team Lead: Assoc. Prof. Borislav Tzankov

  This project supports interdisciplinary work around:

  • RNA constructs and controlled delivery concepts
  • In vitro testing strategies and mechanism-focused evaluation
  • Bioinformatics-driven target logic and interpretation

  MU OmicsLab contributes:

  • target/pathway reasoning for candidate constructs
  • analysis plans and reproducible reporting
  • cross-project bioinformatics support for transcriptomics when applicable

  For project cooperation or student involvement → contact us · свържете се с нас

• Aerosols: air pollutants & cellular response

  Funding: Bulgarian NSF, contract № КП06-Н44-5/13 – 14.07.2021. Principal Investigator/Team Lead: Assoc. Prof. Iliyana Naydenova

  This interdisciplinary project examines:

  • aerosols from biomass conversion and related extracts
  • cytotoxic and oxidative responses in lung cell model systems
  • links between exposure characteristics and biological response

  MU OmicsLab contributes:

  • data analysis and structured reporting
  • support for integrating molecular readouts with phenotypic endpoints
  • reproducible workflows for collaborative interpretation

  Interested in using computational analysis for exposure/tox data? → contact us · свържете се с нас